Erythema nodosum is associated with which of the following conditions?

Erythema nodosum is a condition characterized by painful, tender red nodules that typically appear on the lower legs. It is often considered a hypersensitivity reaction and can be associated with a variety of underlying health issues.

Inflammatory bowel disease, including conditions like Crohn's disease and ulcerative colitis, is well known to be associated with erythema nodosum. This connection is believed to arise due to an inflammatory response that occurs in the body as a result of the bowel disease, leading to systemic manifestations such as skin lesions.

The other conditions listed do not have a significant or established relationship with erythema nodosum. While infectious mononucleosis and other autoimmune conditions might cause skin changes, they are not classic associations. Asthma, primarily a respiratory condition, is also not linked to this type of skin reaction, nor does celiac disease have a strong correlation with erythema nodosum, despite being an autoimmune process. Therefore, inflammatory bowel disease stands out as the correct choice due to its recognized connection with this specific skin manifestation.