Jaundice as an adverse drug reaction (ADR) is most commonly associated with which drug?

Jaundice as an adverse drug reaction is most commonly associated with Vitamin K, particularly when overdosed or used in certain contexts. Vitamin K is crucial for blood clotting, and its overdose can lead to liver dysfunction, which can subsequently cause jaundice. This occurs because excessive amounts of Vitamin K can lead to hepatic injury or hemolysis, both of which contribute to an increase in bilirubin levels, resulting in jaundice.

In contrast, while other drugs listed may have their own potential adverse reactions, they are less commonly linked with jaundice. For example, ibuprofen generally has gastrointestinal and renal side effects, whereas phenobarbital is mostly associated with sedation and dependence issues. Acetaminophen, although it can cause liver damage, typically leads to hepatotoxicity with signs that may not predominantly include jaundice unless there is significant liver failure.

Thus, when considering data regarding drug-induced jaundice, Vitamin K stands out as the drug most notably associated with this particular side effect.