The appearance of a triple bubble sign is most commonly associated with which condition?

The triple bubble sign is primarily associated with duodenal atresia, which occurs when there is a congenital obstruction of the duodenum, preventing the passage of intestinal contents. The appearance of the triple bubble sign on imaging, typically an abdominal X-ray, represents three distinct air-filled sections of the stomach and duodenum, which indicates that the proximal part of the intestine is filled with fluid and air while the part distal to the atresia is not visible due to the blockage.

Duodenal atresia is usually diagnosed in newborns and is often associated with conditions like Down syndrome. The presence of a “double bubble” (stomach and proximal duodenum) plus another bubble from the distal duodenum forms this characteristic appearance.

The other conditions listed may show signs of obstruction or distention, but they do not specifically lead to the triple bubble sign like duodenal atresia does. Jejunal atresia and meconium ileus may present differently on imaging and are characterized by different findings. Intestinal obstruction may show air-fluid levels but does not specifically demonstrate the triple bubble sign associated with the classic presentation of duodenal atresia.