What is a common cause of infertility in females associated with CF?

The association between cystic fibrosis (CF) and infertility in females primarily stems from the presence of thick cervical mucus. In women with CF, the mutation in the CFTR gene leads to the production of abnormal secretions in various glands, including the cervical mucous glands. This thickened mucus can obstruct the passage of sperm through the cervix, making it difficult for fertilization to occur.

While low hormone levels, uterine abnormalities, and age-related factors can contribute to infertility in the general population, they are not specifically linked to cystic fibrosis as a common cause. In women with CF, the thick cervical mucus represents a direct consequence of the disease, significantly impacting their fertility.