What is the characteristic feature of Grey baby syndrome?

Grey baby syndrome is primarily characterized by a distinct grey skin discoloration in neonates, which is caused by exposure to certain medications, particularly chloramphenicol, administered to the mother. This condition is most often seen in infants who are either in the neonatal period or are premature. The term "grey baby" reflects the notable hue of the skin, which can appear greyish or even blue, indicating severe circulatory compromise and toxicity.

This syndrome occurs because the neonatal liver is immature and cannot adequately metabolize and excrete chloramphenicol, leading to toxic levels in the baby. The skin discoloration is a crucial diagnostic sign, often accompanied by other symptoms such as ashen appearance, lethargy, and respiratory issues, but the hallmark is undoubtedly the grey skin coloration.

Understanding the implications and mechanisms of this syndrome is essential for pediatricians and healthcare providers. It highlights the importance of careful medication management in pregnant or breastfeeding women to prevent potential harm to the newborn.