What type of cancer is exstrophy of the bladder related to?

Exstrophy of the bladder is a congenital condition where the bladder and surrounding structures are exposed outside the body due to a failure of normal embryonic development. This significant alteration in the normal anatomy and function of the bladder can lead to various complications, including a heightened risk for malignant transformations.

The most relevant type of cancer associated with exstrophy of the bladder is adenocarcinoma of the urinary bladder. This connection is largely due to the chronic irritation and inflammation the bladder and surrounding tissues undergo over time due to the exposure and alterations inherent in this condition. The continuous exposure and irritation can lead to changes at the cellular level that increase the likelihood of developing malignancies specifically in the urothelial lining, making adenocarcinoma of the bladder the most pertinent type of cancer related to bladder exstrophy.

Other types of cancer, such as neuroblastoma, adrenal carcinoma, or Wilms tumor, are not directly related to the pathophysiological changes ensuing from bladder exstrophy. Each of these cancers has its own unique origins and risk factors that are not linked to the structural abnormalities and complications associated with exstrophy.