Which clinical feature is most commonly associated with Erdheim-Chester disease?

Erdheim-Chester disease is a rare form of non-Langerhans cell histiocytosis characterized by the abnormal proliferation of histiocytes. One of the distinctive clinical features associated with this condition is the presence of certain skin lesions, which can be mistaken for other types of vascular or neoplastic skin manifestations. A strawberry hemangioma, which is a type of capillary malformation that typically appears as a raised, red lesion commonly seen in infants, can sometimes be associated with the vascular components of Erdheim-Chester disease.

The other options provided, such as the persistent Moro reflex, capillary hemangioma, and erythema toxicum, do not align as directly with Erdheim-Chester disease. The persistent Moro reflex is a primitive reflex in infants that typically diminishes as they grow, while capillary hemangiomas are common benign tumors in children that usually resolve over time. Erythema toxicum is a benign neonatal rash that occurs in many infants but is not specifically linked to any systemic disease like Erdheim-Chester disease.

Therefore, the presence of strawberry hemangiomas in some patients with Erdheim-Chester disease highlights the skin manifestations that can occur, making it the most relevant clinical feature among the