Which congenital disorder is associated with thymic atresia?

DiGeorge Syndrome is associated with thymic atresia, which is a condition characterized by the underdevelopment or absence of the thymus gland. The thymus plays a critical role in the immune system, specifically in the maturation of T-cells, which are vital for adaptive immunity. Children with DiGeorge Syndrome often present with immune deficiency as a result of this thymic atresia, making them more susceptible to infections.

DiGeorge Syndrome is a chromosomal disorder caused by a deletion on chromosome 22, leading to a range of developmental abnormalities including cardiac defects, hypoparathyroidism, and facial dysmorphisms, alongside thymic hypoplasia or atresia. The connection between these features underscores the significance of the thymus in immune function and overall health.

The other options—Crouzon syndrome, Marfan syndrome, and Wiskott-Aldrich syndrome—do not have a direct association with thymic atresia. Crouzon syndrome primarily involves craniofacial abnormalities, Marfan syndrome is a connective tissue disorder affecting the skeletal system and cardiovascular health, and Wiskott-Aldrich syndrome is a condition that combines eczema, immunodeficiency, and thrombocytopenia but does not typically involve thymic