Which drug is known to be associated with kidney effects?

Amphotericin B is recognized for its potential nephrotoxicity, which means that it can adversely affect kidney function. This antifungal medication is widely used to treat serious fungal infections, particularly in immunocompromised patients. The mechanism behind Amphotericin B’s kidney-related side effects is primarily related to its action on the renal tubules, leading to significant alterations in the renal blood flow and glomerular filtration rate. This can result in acute kidney injury, often characterized by electrolyte imbalances and decreased urine output.

Understanding the nephrotoxic nature of Amphotericin B is crucial for medical practitioners as they must monitor renal function closely in patients receiving this drug. Depending on the clinical scenario, adjustments to dosage or concurrent use of nephroprotective strategies may be necessary to mitigate the renal effects while still effectively treating fungal infections.

In contrast, while Indomethacin and Ibuprofen are also non-steroidal anti-inflammatory drugs (NSAIDs) that can affect kidney function, their nephrotoxic profile is generally less severe compared to Amphotericin B, especially in a non-overdose setting. Acetaminophen is not primarily associated with kidney toxicity and is usually considered to have a more favorable safety profile regarding renal function.