Which factor is associated with Gilbert's syndrome in adults?

Gilbert's syndrome is a genetic condition characterized by mild, chronic unconjugated hyperbilirubinemia without significant liver disease. It often becomes noticeable during adolescence or adulthood, with bilirubin levels fluctuating.

In adults, emotional stress is known to impact the liver's ability to process and conjugate bilirubin, potentially exacerbating the mild hyperbilirubinemia seen in Gilbert's syndrome. Stress can lead to physiological changes, such as alterations in hormone levels and increased metabolism of bilirubin, which can result in elevated bilirubin levels for those with the syndrome.

While other factors like prolonged fasting or physical exercise can influence bilirubin levels, they generally are not as prominently associated with the fluctuations seen in Gilbert's syndrome in adults as emotional stress is. Excessive hydration typically does not have an adverse impact on the bilirubin levels linked to this condition.