Which is NOT one of the CREAM criteria for Kawasaki disease?

Kawasaki disease is characterized by a set of clinical features, commonly referred to as the CREAM criteria. These criteria help in the diagnosis of this condition, particularly in children. The CREAM acronym stands for Conjunctivitis, Rash, Ewiki (which refers to edema of the hands and feet), Adenopathy (specifically cervical lymphadenopathy), and Mucosal involvement (such as changes in the lips or oral cavity).

In this context, hepatosplenomegaly is not one of the primary features outlined by the CREAM criteria. While hepatosplenomegaly can occur in various childhood illnesses and may be associated with some atypical or complex presentations of Kawasaki disease, it is not a hallmark diagnostic criterion.

The first three options—conjunctivitis, mucosal involvement, and lymphadenopathy—are directly part of the established symptoms that guide healthcare providers in diagnosing Kawasaki disease. Therefore, recognizing that hepatosplenomegaly does not fit within the CREAM criteria confirms the understanding of the diagnostic framework for Kawasaki disease.