Which of the following is true regarding neonatal sepsis?

Maternal colonization with Group B Streptococcus (GBS) is indeed a significant risk factor for neonatal sepsis. GBS can be transmitted to the neonate during delivery, leading to early-onset sepsis. Screening pregnant women for GBS colonization, typically around the 35-37 week mark of gestation, is a common practice to reduce the incidence of GBS-related diseases in newborns. Prophylactic antibiotics during labor for mothers who are found to be GBS positive greatly decrease the risk of the neonate developing sepsis.

While neonatal sepsis affects preterm infants more frequently due to their immature immune systems, it can also occur in full-term infants, so the notion that it only occurs in preterm infants is inaccurate. Diagnosis of neonatal sepsis involves a combination of clinical signs, laboratory tests, and imaging studies, rather than relying solely on clinical appearance. Moreover, although antibiotic treatment is vital in managing neonatal sepsis, it must sometimes be coupled with other interventions depending on the severity of the case, making the statement about it being curable with antibiotics alone overly simplistic.